Daily Health Headlines

propylthiouracil

👤by AP 0 comments 🕔Tuesday, January 13th, 2015

DRUG CLASS AND MECHANISM: Propylthiouracil (PTU) is an oral medication that is used to manage hyperthyroidism which is due to an overactive thyroid gland. It is an anti-thyroid drug that has a mechanism of action that is similar to methimazole (Tapazole). Graves' disease is the most common cause of hyperthyroidism. It is an autoimmune disease where an individual makes antibodies to thyroid stimulating hormone receptors on cells of the thyroid gland and then trigger overproduction of thyroid hormone by the cells. The two thyroid hormones manufactured by the thyroid gland, thyroxine (T4 ) and triiodothyronine (T3), are formed by combining iodine and a protein called thyroglobulin with the assistance of an enzyme called peroxidase. PTU inhibits iodine and peroxidase from their normal interactions with thyroglobulin to form T4 and T3. This action decreases production of thyroid hormone. PTU also interferes with the conversion of T4 to T3, and, since T3 is more potent than T4, this also reduces the activity of thyroid hormones. The FDA approved PTU in July 1947.

PRESCRIBED FOR: PTU is used to manage hyperthyroidism associated with Graves' disease in patients who did not tolerate methimazole, and are not able to receive surgery or radioactive iodine therapy. It also is used to decrease symptoms of hyperthyroidism in preparation for surgical removal of the thyroid gland or before radioactive iodine therapy in patients who did not tolerated methimazole.

Medically Reviewed by a Doctor on 1/13/2015

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Need help identifying pills and medications?Use the pill identifier tool on RxList.

Back to Medications Index

Article Credits / Source

AP / MedicineNet.com

AP wrote this story for MedicineNet.com. MedicineNet.com provides up to the minute breaking health news. Click here to view this full article from MedicineNet.com.

View More Articles From AP 🌎View Article Website

Sponsored Product

Lunar Sleep for $1.95

Lunar Sleep for $1.95

People who have trouble sleeping typically have low levels of melatonin, so melatonin supplements seem like a logical fix for insomnia. There is a high demand for sleep aids, especially in the U.S. The National Health Interview Survey done in 2002, and again in 2007, found 1.6 million US adults were using complementary and alternative sleep aids for insomnia. Lunar Sleep was a top choice. Use Promo Code: Sleep2014 and only pay $1.95 S&H.

Get Lunar Sleep for $1.95

More Thyroid Articles

Thyroid Quiz: Test Your Medical IQ

Thyroid Quiz: Test Your Medical IQ0

The correct answer is: C In the neck Explanation: The thyroid gland is located below the Adam's apple in the lower part of the neck and wraps around the windpipe (trachea). The thyroid gland has the ...

Hashimoto's Thyroiditis

Hashimoto's Thyroiditis0

Hypothyroidism Symptoms Hypothyroidism is most commonly a result of an autoimmune condition known as Hashimoto's thyroiditis. Some of the symptoms of hypothyroidism in adults are: Tiredness and weakness; feeling "run down" Weight gain or ...

Can You Blame Your Headaches on Your Thyroid?

Can You Blame Your Headaches on Your Thyroid?0

THURSDAY, Sept. 29, 2016 (HealthDay News) -- People with migraines and other headache disorders have a greater risk of a thyroid disease known as hypothyroidism, a new study suggests. Hypothyroidism occurs when the body doesn't produce ...

Thyroid Scan

Thyroid Scan0

What is the thyroid gland? The thyroid is a gland that makes and stores essential hormones that help regulate the heart rate, blood pressure, body temperature, and the rate of chemical reactions (metabolism) in the body. It is ...

Thyroid Blood Tests

Thyroid Blood Tests0

Introduction The thyroid gland produces hormones that are essential for normal body metabolism. Blood testing is now commonly available to determine the adequacy of the levels of thyroid hormones. These blood tests can define ...

View More Thyroid Articles

0 Comments

Write a Comment

Your email address will not be published. Required fields are marked *

Our Mailing List

Subscribe to our mailing list to get the latest health news as it breaks!

Your information will not be shared with anyone!