Daily Health Headlines

Cancer Drug Shows Early Promise for Parkinson's Disease

👤by Amy Norton 0 comments 🕔Wednesday, July 13th, 2016

TUESDAY, July 12, 2016 (HealthDay News) -- A drug used to treat leukemia has shown initial signs of promise for advanced cases of Parkinson's disease, researchers are reporting.

Experts stressed that the study was small, and primarily designed to see whether the drug -- called nilotinib (brand name Tasigna) -- is even safe for Parkinson's patients.

It did appear "relatively safe" among the dozen patients studied, said Dr. Charbel Moussa, the senior researcher on the work.

One patient had to withdraw from the study because of heart complications. But the drug was "well tolerated" in the remaining patients, according to Moussa, an assistant professor of neurology at Georgetown University Medical Center, in Washington, D.C.

Plus, he said, there were hints of benefit.

The researchers found signs that the drug boosted the brain's production of dopamine, a chemical that helps regulate movement. It also appeared to reduce certain "toxic proteins" that build up in the brains of people with Parkinson's.

On top of that, the patients typically showed some improvement in both physical symptoms and problems with memory and thinking, the findings showed.

"I think this is a very promising beginning," Moussa said.

But he also emphasized how much remains to be seen.

"We have to be very cautious about the safety profile of this drug in Parkinson's patients," Moussa said. "We also need to clarify the symptom areas that it may benefit, [and] how and when should this drug be used."

That cautious tone was echoed by James Beck, vice president of scientific affairs for the Parkinson's Disease Foundation.

"It's still the early days," said Beck, who wasn't involved in the research.

He pointed to a number of issues that make it difficult to know how nilotinib could fit into Parkinson's treatment, if at all.

For one, the study included only people who were in advanced stages of Parkinson's and had some degree of dementia, including memory loss and thinking problems.

And since the study was designed only as an early "proof of concept," it lacked the rigors that are used in later-stage trials: There was no comparison group given a placebo (inactive treatment), Beck said, and all of the study patients (and researchers) knew they were on the drug.

Moussa acknowledged those limitations. He said his team is planning two trials that will put nilotinib to a tougher test -- where patients will be randomly assigned to take either the drug or a placebo.

One study, Moussa said, will include patients with moderate-stage Parkinson's. The other will focus on people with mild to moderate Alzheimer's disease -- since there is evidence the drug could affect dementia symptoms.

Nearly one million Americans and up to 10 million people worldwide have Parkinson's, according to the Parkinson's Disease Foundation.

It is a chronic, progressive movement disorder that causes tremors, stiffness in the limbs, slowed movement and problems with balance and coordination. Most people also have symptoms that are unrelated to movement, according to the foundation. For some, those include memory issues, fuzzy thinking or even full-blown dementia.

No one is sure exactly what causes Parkinson's, but it involves the death of certain brain cells -- including ones that produce dopamine, which help regulate movement.

For the past 50 years, the mainstay of Parkinson's treatment has been levodopa, a drug that boosts brain dopamine levels.

"But what we've all been waiting for," Beck said, "is a treatment that can actually alter the course of Parkinson's."

According to Moussa, nilotinib "gets more to the roots" of Parkinson's.

The drug belongs to a group of cancer agents called tyrosine kinase inhibitors, which block certain proteins that fuel cancer growth.

Lab research has shown that small amounts of nilotinib can reach the brain, and help cells shed toxic proteins without killing the cell itself, Moussa said.

"The drug acts like a switch," he explained. "It turns on the 'garbage disposal mechanism' in the cell, so it can get rid of toxic proteins."

For the current study, Moussa's team had 12 patients take low doses of nilotinib every day for six months. One patient had to withdraw after one month because he had a heart attack.

Nilotinib carries a boxed warning about potentially risky changes in heart rhythm. That's a concern, Beck said, because Parkinson's patients are generally older and often have other conditions that can raise their risk of heart problems.

He also said the improvements in patients' symptoms are "difficult to interpret."

The improvements happened quickly -- within a month, Beck pointed out. That, he said, suggests a "symptomatic benefit" only, due to higher dopamine levels, rather than any shift in the course of the disease.

With nilotinib already on the market, some patients and doctors might be tempted to try it without more evidence, Moussa acknowledged. But he cautioned against that.

"We should not rush to conclusions," he said.

The study was supported by government and philanthropic funds. Moussa is listed as an inventor on a Georgetown University patent application related to the use of tyrosine kinase inhibitors for treating Parkinson's and other neurodegenerative diseases.

The findings are published in the July 11 issue of the Journal of the Parkinson's Disease.

Article Credits / Source

Amy Norton / HealthDay

Amy Norton wrote this story for HealthDay. HealthDay provides up to the minute breaking health news. Click here to view this full article from HealthDay.

SOURCES: Charbel Moussa, M.D., Ph.D., assistant professor, neurology, Georgetown University Medical Center, Washington, D.C.; James Beck, Ph.D., vice president, scientific affairs, Parkinson's Disease Foundation, New York City; July 11, 2016, Journal of Parkinson's Disease

View More Articles From Amy Norton 🌎View Article Website

Sponsored Product

Lunar Sleep for $1.95

Lunar Sleep for $1.95

People who have trouble sleeping typically have low levels of melatonin, so melatonin supplements seem like a logical fix for insomnia. There is a high demand for sleep aids, especially in the U.S. The National Health Interview Survey done in 2002, and again in 2007, found 1.6 million US adults were using complementary and alternative sleep aids for insomnia. Lunar Sleep was a top choice. Use Promo Code: Sleep2014 and only pay $1.95 S&H.

Get Lunar Sleep for $1.95

More Neurology Articles

Moms' Rheumatoid Arthritis May Be Linked to Epilepsy Risk in Kids

Moms' Rheumatoid Arthritis May Be Linked to Epilepsy Risk in Kids0

WEDNESDAY, Nov. 16, 2016 (HealthDay News) -- Some children born to mothers with rheumatoid arthritis may have higher-than-average odds of developing epilepsy, a new study suggests. Children born to mothers with rheumatoid arthritis were ...

Brain Implant Lets 'Locked-In' ALS Patient Communicate

Brain Implant Lets 'Locked-In' ALS Patient Communicate0

MONDAY, Nov. 14, 2016 (HealthDay News) -- A high-tech implant has enabled a paralyzed woman with late-stage ALS (amyotrophic lateral sclerosis) to communicate through brain signaling, researchers say. The degenerative disease robbed Hanneke De ...

Blood Test May Someday Diagnose Concussion

Blood Test May Someday Diagnose Concussion0

FRIDAY, Nov. 11, 2016 (HealthDay News) -- A simple blood test may one day diagnose concussions with more than 90 percent certainty, a small Canadian study suggests. This new test is unique, the authors said, because it looks for more than 100 ...

gabapentin (Neurontin, Gralise, Horizant, Fanatrex FusePag)

gabapentin (Neurontin, Gralise, Horizant, Fanatrex FusePag)0

home / neurology center / neurology a-z list / gabapentin index / gabapentin (neurontin, gralise, horizant, fanatrex fusepag) drug monograph Pharmacy Author: Omudhome Ogbru, PharmD Omudhome Ogbru, ...

MS Symptoms May Develop Earlier in Darker, Cooler Climes

MS Symptoms May Develop Earlier in Darker, Cooler Climes0

THURSDAY, Nov. 3, 2016 (HealthDay News) -- The farther from the Equator someone with multiple sclerosis lives, the earlier symptoms begin, a new study finds. MS is a progressive disease affecting the central nervous system. Although symptoms ...

View More Neurology Articles

0 Comments

Write a Comment

Your email address will not be published. Required fields are marked *

Our Mailing List

Subscribe to our mailing list to get the latest health news as it breaks!

Your information will not be shared with anyone!