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flibanserin (Addyi)

👤by AP 0 comments 🕔Tuesday, November 3rd, 2015

DRUG CLASS AND MECHANISM:Addyi (flibanserin) is an oral drug used for treating low sexual desire in women. The mechanism of action of flibanserin is not completely understood. Flibanserin affects the way the brain works by interfering with communication among the brain's nerves in areas of the brain that control sexual desire and other pleasurable sensations. Nerves communicate with each other by making and releasing chemicals called neurotransmitters. The neurotransmitters travel to other nearby nerves where they attach to receptors on nerves. The attachment of neurotransmitters either stimulates or inhibits the function of the nearby nerves. Flibanserin blocks several of the receptors on nerves including dopamine type 4, and serotonin type 2A, 2B and 2C receptors. It also stimulates serotonin type 1A. How these effects improve sexual desire in women is unknown. Scientists think that flibanserin may regulate areas of the brain that control sexual desire in premenopausal women with reduced sexual interest and desire. The FDA approved flibanserin on August 18, 2015.

PRESCRIBED FOR: Flibanserin is a prescription medicine used treat premenopausal women with acquired generalized hypoactive sexual desire disorder (HSDD) and are experiencing

low sexual desire, marked distress, or interpersonal difficulty.

The symptoms should not be caused by other medical conditions, problems with the relationship, or effects of other medications. Flibanserin is not used for enhancing sexual performance or for treating HSDD in postmenopausal women or men.

SIDE EFFECTS: The most common side effects of flibanserin are

dizziness, sleepiness (somnolence), nausea, fatigue, insomnia, and dry mouth.

Less common side effects of flibanserin include:

Increased risk of low blood pressure and fainting. The risk of low blood pressure and fainting increases in people with liver failure or people taking medications that reduce the breakdown of flibanserin.

Flibanserin is also associated with

Anxiety Constipation Abdominal pain Rash Vertigo

Medically Reviewed by a Doctor on 11/3/2015

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Pharmacy Author:

Omudhome Ogbru, PharmD

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

Medical and Pharmacy Editor:

Charles Patrick Davis, MD, PhD

Charles Patrick Davis, MD, PhD

Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Article Credits / Source

AP / MedicineNet.com

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