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pygeum (Pygeum africanum)

👤by MedicineNet.com 0 comments 🕔Friday, August 15th, 2014

DRUG CLASS AND MECHANISM: Prunus africanum is a natural herbal supplement. Prunus africanum contains triterpenes, ferulic acid and phytosterols. Ferulic acid lowers prostatic cholesterol levels and phytosterols block prostaglandin synthesis, leading to reduced pain and inflammation. Triterpenes also blocks enzymes responsible for destruction of connective tissues, leading to possible improvement in symptoms of an enlarged prostate. Check with your health care professional before using herbs or herbal supplements.

PRESCRIPTION: No

GENERIC AVAILABLE: Yes

PREPARATIONS: Prunus africanum is available in capsules, liquid extract, and powder form. Concentration of Prunus africanum may vary from product-to-product due to multiple manufacturers producing various products.

STORAGE: Due to multiple manufacturers making different forms of Prunus africanum, storage requirements may vary based on individual manufacturers practices. One commercial product requires storage in a cool dry place.

PRESCRIBED FOR: Prunus africanum is most commonly used for improvement in symptoms of benign prostatic hyperplasia (BPH) such as urinary problems, difficult urination, and prostate inflammation. Less commonly, Prunus africanum is used for fever, stomach ache, malaria, and kidney disease. Check with your health care professional before using herbs or herbal supplements.

DOSING: The recommended dose of Prunus africanum by suppliers is 75 to 200 mg per day. Individuals should consult their doctor before taking Prunus africanum compounds.

DRUG INTERACTIONS: Use with caution with other prostate medications such as finasteride (Proscar) and dutasteride (Avodart) to avoid additive side effects and potential harm.

PREGNANCY: There are no adequate studies of Prunus africanum to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether Prunus africanum enters breast milk; therefore, it is best to be cautious before using it in mothers who are nursing.

SIDE EFFECTS: Side effects of Prunus africanum are nausea, abdominal pain, constipation, and diarrhea.

REFERENCES:

USDA Germplasm Resources Information Network. Genus: Pygeum Gaertn.

National Institutes of Health; Dietary Supplement Label Database. Pygeum Extract.

Medically Reviewed by a Doctor on 8/15/2014

pygeum (Pygeum africanum)-oral Index

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Pharmacy Author:

Omudhome Ogbru, PharmD

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

Medical and Pharmacy Editor:

Charles Patrick Davis, MD, PhD

Charles Patrick Davis, MD, PhD

Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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