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albendazole (Albenza)

👤by MedicineNet.com 0 comments 🕔Friday, November 21st, 2014

DRUG CLASS AND MECHANISM: Albendazole (Albenza) is an oral broad-spectrum anthelmintic agent that is used to eradicate various parasitic worms from the body. Albendazole is effective in treating infections caused by a variety of parasites including Echinococcus granulosus (dog tapeworm), Taenia saginata (beef tapeworm), Taenia solium (pork tapeworm), Trichinella spiralis (pork worm), Trichuris trichiura (whipworm), Enterobius vermicularis (pinworm), Strongyloides stercoralis (threadworm), Ascaris lumbricoides (roundworm), Ancylostoma duodenale (hookworm), and Necator americanus (hookworm).

After oral administration the active metabolite, albendazole sulfoxide, prevents formation of microtubules in cells of parasitic worms and larvae. Microtubules are found in both the parasite and host cells and are necessary for survival. Microtubules have various functions such as cell division, organization of intracellular structure and intracellular transport. Albendazole selectively destroys microtubules of the parasites but not of the host. Destruction of the microtubules is irreversible and leads to a decrease in glucose uptake, depletion of glycogen stores, and accumulation of secretory substances inside the cell, and the subsequent immobilization and eventual death of the parasite. Albendazole was approved by the US Food and Drug Administration in June 1996.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No (beware of fraudulent suppliers)

PREPARATIONS: Tablets: 200 mg

STORAGE: Tablets should be stored at room temperature between 20 C to 25 C (68 F to 77 F).

Medically Reviewed by a Doctor on 11/21/2014

albendazole-oral Index albendazole-oral on RxList

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Pharmacy Author:

Omudhome Ogbru, PharmD

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

Medical and Pharmacy Editor:

Charles Patrick Davis, MD, PhD

Charles Patrick Davis, MD, PhD

Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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