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evolocumab (Repatha)

👤by AP 0 comments 🕔Monday, December 14th, 2015

DRUG CLASS AND MECHANISM: Evolocumab is a man-made injectable drug that reduces cholesterol levels in the blood. It is the second member of a new class of drugs called proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors.

Cholesterol is carried in the blood to a large extent by particles called low density lipoproteins (LDL, also known as "bad" cholesterol). The LDL particles are removed from the blood by first attaching to receptors (LDLR) that are on the surface of liver cells. PCSK9 is a protein produced by liver cells that promotes the destruction of LDLR. Destruction of LDLR levels results in higher blood levels of LDL cholesterol.

Evolocumab is an antibody, which means that it is a protein that binds to another protein and inactivates it. Evolocumab binds to the PCSK9 and prevents it from destroying LDLR. The increase in the number of LDLRs results in greater removal of LDL cholesterol from the blood and lower cholesterol levels in blood. The FDA approved evolocumab in July 2015.

PRESCRIBED FOR: Evolocumab is used along with diet, exercise and maximum tolerated doses of statins to reduce LDL cholesterol in adults with heterozygous or homozygous familial hypercholesterolemia (inherited disorders that cause high levels of LDL) or adults with heart problems related to excess cholesterol in the body.

Medically Reviewed by a Doctor on 12/14/2015

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Pharmacy Author:

Omudhome Ogbru, PharmD

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

Medical and Pharmacy Editor:

Jay W. Marks, MD

Jay W. Marks, MD

Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Article Credits / Source

AP / MedicineNet.com

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