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cholestyramine, Questran, Questran Light

👤by AP 0 comments 🕔Tuesday, December 30th, 2014

DRUG CLASS AND MECHANISM: Cholestyramine is an oral medication that reduces the levels of cholesterol in the blood and improves the itching associated with liver disease. Cholesterol that is ingested or manufactured in the body is eliminated primarily by conversion to bile acids in the liver and excretion into the intestine with bile. The bile enters the intestine, and most of the bile acids are reabsorbed from the intestine. These reabsorbed bile acids are removed from the blood by the liver and excreted again into bile. Thus, bile acids re-circulate in the body. Cholestyramine binds to bile acids in the intestine. This prevents their absorption, and the cholestyramine/bile acid complexes are eliminated in the stool. As a result, the body loses bile acids. To compensate for this loss, the liver increases the conversion of cholesterol to bile acids. The conversion of cholesterol to bile acids reduces the cholesterol in the body, and the levels of cholesterol drop in the blood.

One of the most troubling symptoms in patients with liver and biliary disease is itching. The itching is believed in some cases to be the result of accumulation of bile acids in the skin due to the inability of the liver or bile ducts to eliminate bile acids normally. By binding bile acids in the intestines and preventing their absorption, cholestyramine hastens the elimination of bile acids from the body and skin, and the itching improves. Cholestyramine also binds some drugs in the intestine, preventing their absorption and hastening their elimination. Therefore, cholestyramine is useful in some situations in which there has been an overdose of drugs. The FDA approved cholestyramine in August 1973.

Medically Reviewed by a Doctor on 12/30/2014

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Pharmacy Author:

Omudhome Ogbru, PharmD

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

Medical and Pharmacy Editor:

Jay W. Marks, MD

Jay W. Marks, MD

Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Article Credits / Source

AP / MedicineNet.com

AP wrote this story for MedicineNet.com. MedicineNet.com provides up to the minute breaking health news. Click here to view this full article from MedicineNet.com.

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