Daily Health Headlines

DNA Mapping May Lead to Personalized Cancer Treatment

👤by HealthDay 0 comments 🕔Thursday, November 10th, 2016

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- DNA sequencing may help personalize treatment for people with lymphoma, a new study suggests.

By analyzing small bits of DNA in the blood, researchers at Stanford University School of Medicine said they could determine the cancer's subtype. They said they could also identify mutations that might make treatment less effective or worsen a patient's prognosis.

The study authors said their findings add to growing evidence that noninvasive, blood-based biopsies may help detect cancer earlier by tracking its evolution. They said this test may also significantly change how the disease is treated.

"Now we can identify the subtype of the tumor, watch how it changes over time and begin to tailor our chemotherapy choices based on the presence or absence of specific mutations," said study co-senior author Dr. Ash Alizadeh, an assistant professor of medicine/oncology.

"We've moved beyond just measuring disease burden based on the amount of tumor DNA in the blood," Alizadeh said in a university news release.

The study included 92 people. They all had a common form of non-Hodgkin lymphoma known as diffuse large B-cell lymphoma. The disease is biologically diverse. That means patients with this disease tend to respond very differently to treatments, the researchers explained.

Roughly one-third of those with the disease relapse, or develop treatment resistant tumors, the researchers said. The researchers also said that some people with mild, slowly progressing forms of the disease may suddenly develop aggressive cancer.

Using an advanced DNA sequencing technique, the research team pinpointed circulating tumor DNA in samples of the patients' blood. They compared these results with previous blood samples that were taken from the patients, as well as blood samples of tumor cells from invasive biopsies.

"This transformation is very difficult to detect, and usually requires an invasive biopsy to diagnose," said study co-senior author Dr. Maximilian Diehn. He's an assistant professor of radiation oncology at Stanford.

"Our approach will allow us to monitor patients over time with a simple blood test, and may help us identify transformation much earlier," Diehn said.

The study showed that low levels of circulating tumor DNA before treatment began were associated with progression-free survival. Higher levels of tumor DNA were linked with a worse overall disease outlook.

The researchers said they were able to detect the cancer's presence in the blood of patients who were relapsing six months before any symptoms appeared. In some cases, the blood test was able to predict a recurrence up to 2.5 years before symptoms appeared, the researchers said.

The study's authors said they were also able to use this DNA sequencing technique to figure out the type of cell from which the cancer originated. This helped the researchers predict a patient's prognosis. The researchers said they could also predict which patients would develop aggressive lymphoma even before symptoms were seen.

"In this study we've shown five distinct ways -- by quantifying tumor burden, identifying disease subtype, cataloging mutations, predicting transformation and providing early warnings of recurrence -- that circulating tumor DNA can yield potentially clinically useful information," Diehn said.

"Now we're eager to conduct prospective studies in recently diagnosed patients to learn how we can best improve patient care," he added.

The study was published Nov. 9 in Science Translational Medicine.

-- Mary Elizabeth Dallas

Article Credits / Source


HealthDay provides up to the minute breaking health news. Click here to view this full article from HealthDay.

SOURCE: Stanford University School of Medicine, news release, Nov. 9, 2016

View More Articles From HealthDay 🌎View Article Website

Sponsored Product

Lunar Sleep for $1.95

Lunar Sleep for $1.95

People who have trouble sleeping typically have low levels of melatonin, so melatonin supplements seem like a logical fix for insomnia. There is a high demand for sleep aids, especially in the U.S. The National Health Interview Survey done in 2002, and again in 2007, found 1.6 million US adults were using complementary and alternative sleep aids for insomnia. Lunar Sleep was a top choice. Use Promo Code: Sleep2014 and only pay $1.95 S&H.

Get Lunar Sleep for $1.95

More Cancer Articles

No Benefit From Routine Thyroid Cancer Screening: Task Force

No Benefit From Routine Thyroid Cancer Screening: Task Force0

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Doctors should not screen for thyroid cancer in patients who have no symptoms of the disease, according to a U.S. Preventive Services Task Force draft recommendation. It reaffirms a recommendation ...

Depressed Women Less Likely to Get Best Breast Cancer Care: Study

Depressed Women Less Likely to Get Best Breast Cancer Care: Study0

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Breast cancer patients with a history of depression are less likely to receive recommended care for their disease, a new study finds. The study included more than 45,000 Danish women diagnosed with ...

Earnings Fall After a Child's Cancer Diagnosis

Earnings Fall After a Child's Cancer Diagnosis0

MONDAY, Nov. 21, 2016 (HealthDay News) -- After a child's cancer diagnosis, parents' income often drops and mothers frequently stop working, a new study finds. Moreover, the financial effects of a cancer diagnosis can last years, with mothers' ...

Monoclonal Antibodies

Monoclonal Antibodies0

home / cancer center / cancer a-z list / monoclonal antibodies index / monoclonal antibodies drug monograph Pharmacy Author: Omudhome Ogbru, PharmD Omudhome Ogbru, PharmDDr. Ogbru received his ...

New Drug May Brighten Outlook for Advanced Breast Cancer

New Drug May Brighten Outlook for Advanced Breast Cancer0

WEDNESDAY, Nov. 16, 2016 (HealthDay News) -- A recently approved drug can help slow the progression of advanced breast cancer, a new clinical trial confirms. The drug, called palbociclib (Ibrance), was approved in the United States last year ...

View More Cancer Articles


Write a Comment

Your email address will not be published. Required fields are marked *

Our Mailing List

Subscribe to our mailing list to get the latest health news as it breaks!

Your information will not be shared with anyone!