Daily Health Headlines

14 Genes That May Affect Cancer Treatment

👤by HealthDay 0 comments 🕔Wednesday, August 31st, 2016

WEDNESDAY, Aug. 31, 2016 (HealthDay News) -- Researchers say they've identified 14 genes that may help determine whether a cancer treatment could help a patient.

The researchers also say the findings suggest it could be possible to help people avoid unnecessary cancer treatments that won't likely benefit them.

"The history of cancer treatment is filled with overreaction," said principal investigator Gary Karpen, a senior scientist at the U.S. Department of Energy's Lawrence Berkeley National Laboratory in Berkeley, Calif.

"It is part of the ethics of cancer treatment to err on the side of overtreatment, but these treatments have serious side effects associated with them. For some people, it may be causing more trouble than if the growth was left untreated," Karpen said in a Berkeley Lab release.

However, there has not been a reliable way to determine which early stage cancer patients will respond to chemotherapy and radiation therapy, according to study author Weiguo Zhang. He's a project scientist at Berkeley Lab.

"For certain types of early stage lung cancer patients, there are estimates that adjuvant chemotherapy improves five-year survival only about 10 percent, on average, which is not great considering the collateral damage caused by this treatment (chemotherapy)," Zhang explained.

"Even for early stage cancer patients, such as lung cancers, adjuvant chemotherapy and radiotherapy are routinely used in treatment, but overtreatment is a major challenge," Zhang said.

The researchers found 14 genes that consistently "over-express" in a large number of cancers. When a gene "expresses," it's essentially releasing a set of instructions, according to the U.S. National Human Genome Research Institute.

The study team then created a scoring system based on the degree of over-expression. A higher score meant more over-expression in those genes.

For several types of major cancers, the higher the score, the worse the prognosis for patients. But "another finding -- one that is counterintuitive -- is that high expression of these genes is also related to more effective chemotherapy and radiation therapy," said Karpen. The scores could then lead to predicting patient response to specific cancer treatments, according to the study team.

A genetic marker could prove valuable when deciding whether to use a particular therapy or not, but translating these study findings into clinical practice will require more research, the study authors noted.

The study was published Aug. 31 in the journal Nature Communications.

-- Robert Preidt

Article Credits / Source

HealthDay

HealthDay provides up to the minute breaking health news. Click here to view this full article from HealthDay.

SOURCE: Lawrence Berkeley National Laboratory, news release, Aug. 31, 2016

View More Articles From HealthDay 🌎View Article Website

Sponsored Product

Lunar Sleep for $1.95

Lunar Sleep for $1.95

People who have trouble sleeping typically have low levels of melatonin, so melatonin supplements seem like a logical fix for insomnia. There is a high demand for sleep aids, especially in the U.S. The National Health Interview Survey done in 2002, and again in 2007, found 1.6 million US adults were using complementary and alternative sleep aids for insomnia. Lunar Sleep was a top choice. Use Promo Code: Sleep2014 and only pay $1.95 S&H.

Get Lunar Sleep for $1.95

More Cancer Articles

No Benefit From Routine Thyroid Cancer Screening: Task Force

No Benefit From Routine Thyroid Cancer Screening: Task Force0

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Doctors should not screen for thyroid cancer in patients who have no symptoms of the disease, according to a U.S. Preventive Services Task Force draft recommendation. It reaffirms a recommendation ...

Depressed Women Less Likely to Get Best Breast Cancer Care: Study

Depressed Women Less Likely to Get Best Breast Cancer Care: Study0

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Breast cancer patients with a history of depression are less likely to receive recommended care for their disease, a new study finds. The study included more than 45,000 Danish women diagnosed with ...

Earnings Fall After a Child's Cancer Diagnosis

Earnings Fall After a Child's Cancer Diagnosis0

MONDAY, Nov. 21, 2016 (HealthDay News) -- After a child's cancer diagnosis, parents' income often drops and mothers frequently stop working, a new study finds. Moreover, the financial effects of a cancer diagnosis can last years, with mothers' ...

Monoclonal Antibodies

Monoclonal Antibodies0

home / cancer center / cancer a-z list / monoclonal antibodies index / monoclonal antibodies drug monograph Pharmacy Author: Omudhome Ogbru, PharmD Omudhome Ogbru, PharmDDr. Ogbru received his ...

New Drug May Brighten Outlook for Advanced Breast Cancer

New Drug May Brighten Outlook for Advanced Breast Cancer0

WEDNESDAY, Nov. 16, 2016 (HealthDay News) -- A recently approved drug can help slow the progression of advanced breast cancer, a new clinical trial confirms. The drug, called palbociclib (Ibrance), was approved in the United States last year ...

View More Cancer Articles

0 Comments

Write a Comment

Your email address will not be published. Required fields are marked *

Our Mailing List

Subscribe to our mailing list to get the latest health news as it breaks!

Your information will not be shared with anyone!