Daily Health Headlines

Zurampic Approved for Gout

👤by Scott Roberts 0 comments 🕔Thursday, December 24th, 2015

WEDNESDAY, Dec. 23, 2015 (HealthDay News) -- Zurampic (lesinurad) has been approved by the U.S. Food and Drug Administration to control blood levels of uric acid associated with gout.

Gout, a form of arthritis, commonly emerges as pain, redness and swelling in the big toe. Uric acid normally is a natural waste product that's passed through the kidneys. But when it builds up in the body, crystals may form and lead to gout.

Zurampic, approved in combination with a second drug called xanthine oxidase, helps the kidneys avoid reabsorbing uric acid, then aids the kidneys in excreting uric acid from the body, the FDA said in a news release.

Zurampic was evaluated in clinical studies involving more than 1,500 people. Those treated with the drug combination saw a drop in uric acid levels, compared to those who took placebos.

The most common side effects of Zurampic included headache, a rise in a blood compound called creatinine, flu and chronic heartburn (gastroesophageal reflux disease).

Zurampic's label will include a boxed warning of the possibility of kidney failure if it is used without the second drug, or at higher-than-approved doses, the FDA said.

The agency said it ordered Zurampic's Delaware-based manufacturer AstraZeneca to conduct additional trials to further evaluate the drug's effects on the kidneys and heart.

-- Scott Roberts

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Scott Roberts / HealthDay

Scott Roberts wrote this story for HealthDay. HealthDay provides up to the minute breaking health news. Click here to view this full article from HealthDay.

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