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Wegener's Granulomatosis

👤by MedicineNet.com 0 comments 🕔Friday, April 24th, 2015

Wegener's granulomatosis facts

Wegener's granulomatosis is an uncommon disease that involves inflammation of blood vessels (vasculitis). Symptoms of Wegener's granulomatosis include: fatigue, weight loss, fevers, shortness of breath, bloody sputum, joint pains, and sinus inflammation. Diagnosis of Wegener's granulomatosis is confirmed by detecting both abnormal cellular formations, called granulomas, and vasculitis. Treatment is directed toward stopping the inflammation process by suppressing the immune system.

What is Wegener's granulomatosis?

Wegener's granulomatosis is an uncommon type of inflammation of small arteries and veins (vasculitis). It classically involves inflammation of the arteries that supply blood to the tissues of the lungs, the nasal passages(sinuses), and the kidneys. "Incomplete" forms exist that only involve one of these areas. When both lungs and kidneys are affected, the condition is sometimes referred to as generalized Wegener's granulomatosis. When only the lungs are involved, the condition is sometimes referred to as limited Wegener's granulomatosis. Wegener's granulomatosis is also referred to as granulomatosis with polyangiitis (abbreviated GPA). The terminology "granulomatosis with polyangiitis" highlights the two central pathologic features of the disease, granuloma formation and inflammation of blood vessels (angiitis or vasculitis).

Wegener's granulomatosis usually affects young or middle-aged adults. Although it is uncommon in children, it can affect people at any age. The cause of Wegener's granulomatosis is not known.

Medically Reviewed by a Doctor on 4/24/2015

Wegener's Granulomatosis Index

Patient Comments Viewers share their comments

Wegener's Granulomatosis - Symptoms Question: What were the symptoms of your Wegner's granulomatosis?

Wegener's Granulomatosis - Treatment Question: What was the treatment for Wegener's granulomatosis in you, a friend, or relative?

Wegener's Granulomatosis - Experience Question: Please share your experience with Wegener's granulomatosis.

Medical Author:

William C. Shiel Jr., MD, FACP, FACR

William C. Shiel Jr., MD, FACP, FACR

Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Joint Pain Symptoms and Signs Joint pain is also referred to as arthralgia. Pain is a feature symptom of joint inflammation with diseases and conditions such as rheumatoid arthritis and osteoarthritis. Joint pain also may be caused by an injury to the ligaments, bursae, tendons, bones, and cartilage surrounding and within the joint. Joint pain also is a symptom of Wegener's granulomatosis. Pain within the joint is a common cause of shoulder pain, ankle pain, and knee pain.

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